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AYUREDI, from an ayurvedic plant to a holistic anti-ageing active ingredient

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AYUREDI, from an ayurvedic plant to a holistic anti-ageing active ingredient

Sourced by Expanscience in Thailand, in the Chiang Mai region (north of Thailand), holy basil (Ocimum Sanctum​), commonly known in the Hindi language as tulsi, is a very well-known plant used in Ayurvedic medicine.

Acting as an adaptogenic plant, helping the body adapt to stress and find deep reserves of energy, holy basil is considered as an "elixir of life”.

Inspired by its traditional uses and benefits, Expanscience is launching AYUREDI, a new active ingredient extracted from holy basil leaves.

Rich in polyphenols, AYUREDI protects the skin against daily stresses (physical and psychological) and restores the skin’s balance for a serene skin. 

Exposome and​ skin homeostasis

According to Ayurveda, the oldest holistic medicine in the world, serenity, health and longevity are linked to the balance of your doshas (mind-body connection). Vata, Pitta and Kapha are the three doshas that represent your physical processes, personality and emotional traits. They can even reflect your skin profile and will thus change through life depending on your exposome.

The exposome includes UV light, pollution, nutrition, psychological stress, lack of sleep and other stress factors. In addition to chronological ageing, exposome accelerates skin ageing, unbalancing the skin homeostasis.

All these factors lead to chronic, persistent and underlying inflammation: this is the inflamm’ageing. As a result, the skin's defense system is exhausted, weakening the skin structure: the degradation of collagen and elastin and impairment of the skin's barrier function. Wrinkles deepen, the skin becomes less firm and loses its radiance.

“Studies conducted in twins demonstrate that approximately 25% of the variation in human longevity is due to genetic factors, while the rest is due to individual behavior and environmental factors”. 1

This means that the remaining 75%, represented by the exposome, lies in our hands.    

The impact of oxidative stress on the skin is now well known, and studies confirm its contribution to the appearance of visible signs of ageing due to barrier function alteration, DNA damage and cell energy production decrease.2

In response to this inflamm’ageing phenomenon and in order to slow it down, AYUREDI fights against skin-ageing.

PF 1

AYUREDI acts on three skin pathways making it a holistic anti-ageing active ingredient:

  • Cell defenses are reinforced to fight skin-ageing
  • Cell energy and breathing are boosted to illuminate the skin
  • Cells are relaxed to soothe the skin

AYUREDI protects skin against psychological stress

As previously detailed, oxidative stress can be induced by exposome, such as pollution and UV exposure, as well as psychological stress.

Nowadays psychological stress is increasingly strong and therefore has a greater impact on skin quality and ageing.

These impacts result from cortisol, which is the main stress hormone in our body. In a chronic stress situation, high levels of cortisol are secreted, generating high levels of oxidative stressors that in turn impact the skin.

In cortisol stress conditions, results show that AYUREDI decreases the production of free radicals to protect the skin. Moreover, hydrolipidic film is preserved as lipid peroxidation levels are decreased under pollution stress with AYUREDI. The skin barrier function is thus maintained, and the skin regains its healthy level.

AYUREDI​ restores cellular production of the “king” of antioxidants (glutathione)

Studies further demonstrate that AYUREDI restores antioxidative defense, specifically against DNA damage and telomere shortening.

Very well-known ageing markers and chromosome “protectors”, telomeres are the caps at the end of each DNA’s strand.

Expanscience’s studies demonstrate that AYUREDI restores the cellular production of glutathione, the most powerful antioxidant of our organism, and that it also can trigger telomeres’ growth.

By increasing the skin’s own defense capabilities, AYUREDI preserves it from ageing.

AYUREDI​ boosts skin energy source

Exposome impacts also the skin energy source by disturbing mitochondrial functions.3​ As the energy factories of our cells, mitochondria produce ATP, an energetic intermediary compound essential for cellular life.

Mitochondrial damage leads to a decrease in respiratory capacity and cellular energy production and then ultimately to cells ageing and senescence.

Under pollution stress, AYUREDI  has been demonstrated to protect mitochondria and restore their essential functions.

AYUREDI, a holistic anti-ageing ingredient: in-vitro results confirmed by clinical study

A 56 day-long double-blind clinical study (AYUREDI 3% vs​ placebo) conducted on 2 groups of 22 and 23 women (average 53 years old, phototype I to III) has demonstrated significant results:

-          wrinkles are visibly reduced (crow’s feet: wrinkles’ area -13.2% and wrinkles’ length -13. 9%)

-          skin firmness is improved (tonicity +14% and elasticity +15%)

-          complexion regains its radiance and is unified

-          skin texture is improved

All these studies confirm that AYUREDI is acting as a holistic anti-ageing active ingredient: it protects the skin against daily stresses (physical & psychological) and restores the skin’s balance for a serene skin.    

Fully natural*​ and COSMOS Approved**​, AYUREDI is already available!

Footnotes

1​ Passarino G et al. Human longevity: Genetics or Lifestyle? It takes two to tango, Immun Ageing,​ 2016, vol 13, pp. 12

2​ Mark Rinnerthaler et al. Oxidative Stress in Aging Human Skin, Biomolecules​, 2015, vol 5(2), pp. 545-589

3​ Matej Orešič et al., Metabolic Signatures of the Exposome - Quantifying the Impact of Exposure to Environmental Chemicals on Human Health, Metabolites​, 2020, vol 10, pp. 454

* INCI: Propanediol, Water, Ocimum Sanctum Leaf Extract (Ok worldwide, IECIC 2015 listed)

**​ Raw material approved by Ecocert Greenlife, conform to the COSMOS Standard.

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