Silab launches skin detoxification ingredient

The France-based company says that during the development of the new ingredient it identified and targeted the skin’s natural detoxification system, which is composed of two complimentary mechanisms : the proteasome and autophagy.

Extensive research has already been carried out in this field by neurologists, and Silab’s research and development team decided they would build on this to develop the ingredient.

The research team discovered that, although research into the proteasome area was extensive, the body of research on the autophagy area was still relatively limited, despite the fact that this detoxification system is known to be a powerful compliment to the proteasome at a basal level.

Research concentrated on the autophagy system​

To investigate this relationship further the Silab researchers teamed up with the University of Limoge, in France to further investigate this detoxification process, the first extensive dermocosmetic research in this area of its kind.

The joint research project culminated in the development of the Celldetox active ingredient, which is isolated and purified from Candida saitoana, a fungi obtained from a fermentation process.

Silab says that the detoxification process of the ingredient helps to reduce the signs of ageing, restoring the skin’s natural radiance and can be used in a variety of detoxifying and repairing skin care products.

Clinical studies show reduced oxidation and better complexion​

Clinical studies using a 1 percent dose of the ingredient shows that the synthesis of LC3 protein, a marker of autophagosomes, was boosted by 19 per cent, while there was also notable improvements in the formation of lysosomes, which are responsible for the degradation of the cell residues.

Likewise, a 3 per cent dose also bought about a 13.9 per cent reduction in the quantity of oxidized proteins, while the same dose also reduced the quantity of preoxidized lipids by 23.4 per cent.

Ultimately Silab says that proof of the ingredient's efficacy can be seen in visible improvements to the skin's quality and overall complexion.

An expert trained in the assessment of skin complexion and radiance, found that there was a 10.7 per cent increase in pink colour, a 9.4 per cent increase in transparency and an 8 per cent increase in skin reflection.