Bioiberica’s hyaluronic acid improves aesthetic markers for aging skin: Study

By Olivia Haslam

- Last updated on GMT

© Jonathan Storey / Getty Images
© Jonathan Storey / Getty Images

Related tags Bioiberica Collagen hyaluronic acid anti ageing Skin

Bioiberica's hyaluronic acid (HA) matrix ingredient Dermial showed anti-aging skin benefits, according to new research presented at Vitafoods Europe.

Dermial has been designed to improve the effects of standard HA, Daniel Martínez-Puig, head of R&D human and animal health told NutraIngredients, and the new research has shown visible improvements to aging skin.

The first human clinical trial to be conducted with the ingredient investigated the effect of either 60 mg/day Dermial or placebo in 60 women between the ages of 35 and 65 over 12 weeks.

The results, yet to be published, suggested supplementation improved skin hydration and reduced wrinkles. 

Healthy aging skin

Hyaluronic acid is gaining increasing consumer and industry attention; according to FMCG Gurus Healthy 2022 aging skin report, 34% of consumers associate the ingredient with skin health, and the hyaluronic acid personal care product market is forecasted to grow by 8% between 2023 and 2033, according to Future Market Insights data.

The naturally occurring polysaccharide is present in the dermis and epidermis of the skin where its main function is to bind water to collagen, trapping water and maintaining skin hydration. 

Levels of hyaluronic acid decrease with age, which can lead to loss of elasticity, increased dryness and fragility. This infers the need for supplementation, Martínez-Puig noted, explaining that hyaluronic acid supplements are absorbed in the intestines and accumulate in the connective tissue, including in the skin.

Dermial contains a high concentration of HA (60-75%), plus other constituents such as sulfated glycosaminoglycans and collagen, designed to work in synergy and offer improved results to standard HA supplementation. Previous research​ indicates that Dermial could improve type I collagen by 48% in comparison to fermentation-origin HA.

As Martínez-Puig explained, the ingredient is positioned to appeal to consumers interested in the growing category of ‘agelessness’.​ 

“The results we’ve seen align with this anti-aging trend, as with the aging process, what you see is more wrinkles, less hydrated skin, and more dryness,” he said. “Yet our results show a true rebalancing in the aging process.”

Dermial results 

Martínez-Puig previewed the results of the latest study, noting that daily Dermal supplementation increased skin brightness by 20% at six weeks and by 34% at 12 weeks. 

Statistically significant differences were also observed in wrinkle reduction between Dermial and the placebo group after six weeks. Additionally, hydration of the stratum corneum (the outermost layer of the epidermis), dryness, skin temperature and erythema index (redness of skin) were significantly improved in the Dermial group versus baseline at six weeks.  

As Martínez-Puig noted, participant perception was also improved, as consumer satisfaction was significantly higher in supplemented women (69%) in comparison to the placebo group (42%).

Previous in vitro​ research​ found that in comparison to standard HA, Dermial improved the synthesis of type I collagen, supported the proliferation of human dermal fibroblasts (HDF) cells at a significantly higher rate and increased the migration of HEK cells.

"From this research, we knew that Dermial could offer regenerative activity to the dermis and epidermis layers of the skin and support the maintenance and functionality of the dermis better than standard HA," Martínez-Puig said.

“Now with this human clinical trial, we have proof of the superior effect in terms of collagen I production.”


Journal: Journal of Investigative Dermatology, 2024.​ (In press).
Authors: Galvez-Martin, P et al.

Related news

Related products

show more

Calendula Cellular Elixir: Alchemy in a cell

Calendula Cellular Elixir: Alchemy in a cell

Content provided by Naolys | 24-Apr-2024 | Product Brochure

Get ready to experience a cellular evolution in skincare with InnerLift Calendula's advanced Plant Cell biotechnology.

See our latest innovations in personal care

See our latest innovations in personal care

Content provided by Covation Bio™ PDO | 02-Apr-2024 | White Paper

At CovationBio PDO, we’re helping the world achieve its sustainability goals by enabling better performing, better-for-the planet products across a range...

Collagen Reimagined, Discover Biodesigned Type XXI

Collagen Reimagined, Discover Biodesigned Type XXI

Content provided by Geltor | 20-Mar-2024 | Product Brochure

Collagen is the body’s most abundant protein and a mainstream ingredient for beauty. Type XXI collagen transcends a common protein into a powerful bioactive

Empowering natural barrier function for future-proof skin

Empowering natural barrier function for future-proof skin

Content provided by Lucas Meyer Cosmetics | 14-Mar-2024 | White Paper

Corneopeptyl™ is a new patented peptide biomimetic to the LCE6A protein, obtained by green chemistry-based synthesis. By mimicking the LCE6A protein activity,...

Related suppliers

Follow us


View more



Beauty 4.0 Podcast