Anti-cellulite ingredient fights orange peel skin on multiple levels, claims Provital

According to the company, Provislim can work to reduce deposits of fat in the adipose tissue; an abundance of which can lead to skin irregularities and the orange peel appearance.

Designed to work through multiple pathways, the ingredient is a combination of a natural flavonoid fisetin, derived from the smoketree (Buxus sinica​) and frambinone, a phenolic compound derived from the anise plant.

Raising lipolysis at rest and during activity​

Primarily, the phenolic compound frambinone can help raise the level of lipolysis (the breakdown of triglycerides into free fatty acids for use by cells or as energy) when the body is at rest, Provital claims.

In addition, the compound can help raise the level of lipolysis during exercise, according to the company.

Hormones released during exercise and stress will naturally raise the level of triglyceride breakdown, making more fatty acids available for energy. However, according to Provital, the presence of frambinone can help increase this breakdown even more.

Inhibits lipogenesis​

The fisetin part of the ingredient has both antioxidant and anti-inflammatory effects; but, the company also claims it has the effect of diminishing the conversion of glucose into fats after eating.

This lipogenesis-inhibiting effect is due to the ingredient’s inhibition of the activation of the PI3K enzyme that is key in getting glucose into the cell.

Combining these two compounds creates an ingredient that can attack cellulite by activating triglycerides degradation, both at rest and during activity, as well as inhibiting the formation of triglycerides after food intake, and inhibiting the differentiation of pre-adipocytes into mature adipocytes.

In vivo ​testing​

In vitro​ tests were performed by the company to investigate these active pathways, as were in vivo​ tests using a formulation containing Provislim and comparing its action to a placebo.

According to the company, after 56 days of application, using a placebo formulation on one leg and the Provislim-containing one on the other, there was a reduction in thigh diameter and an improvement in skin appearance. The average decrease in diameter was 0.3cm, with a maximum decrease of 1cm.