New data from Rahn points to remedy for epidermal jetlag

The company has performed additional clinical trials on its Celligent ingredient, that boost the claims for the skin care ingredient, giving it scope for wider uses and tapping into a rising trend in skin care: skin fatigue from travel and other environmental hazards.

Celligent was first launched seven years ago as a biological active ingredient with skin repair capabilities by targeting stem cell and DNA protection.

Targeting the preprogrammed circadian rhythm​

For the latest research into the ingredient, the Rahn team focused on pre-programmed circadian rhythm, which is activated when eyes perceive the blue light spectrum and is determined by clock genes such as CLOCK, ARNTYL, PER and CRY.

If this rhythm is disturbed, the clock genes are disturbed, which is what happens when sleep patterns are disturbed, just like jetlag, but also due to long working days and usage of blue light emitting devices  which can damage the skin at the cellular level.

The Rahn development team claims that the powerful antioxidants obtained from rice and rosemary in Celligent can recalibrate this biorhythm, strengthening the skin barrier, increasing moisture and eliminating redness.

The results of Rahn’s clinical trials​

• Recalibrates circadian clock genes after UV stress (in-vitro ​study)
• Protects against DNA damage, blue light-induced ROS formation and lipid peroxidation (in-vitro ​study)
• Protects epidermal stem cells against UV-related performance drop-down (in-vitro ​study)
• Protects the skin against formul’ageing (ex-vivo ​study)
• Preserves the circadian rhythm, strengthens the skin barrier and reduces light stress symptoms (in-vivo ​study)
• Regenerates skin after UV-related damage (in-vivo ​study)
• Protects formulations against formul’ageing (in-formulation ​study)
• Reduces UV-induced radical formation in colour cosmetics (in-formulation ​study)

What Celligent is made up of​

The active ingredient complex has been designed to protect and treat skin against stresses such as UV exposure, claims that have been built on with the latest research from the Rahn team.

The ingredient combines three active principles that interlock: Ehtyl ferulate, a natural antioxidant with UV absorbing properties; carnosolic acid to combat free radicals and uridine monophosphate, which supports the repair of DNA in skin cells.

The Rahn development team suggest that a dosing a measuring of between 0.5% to 3% is sufficient for most skin care formulations.