Mibelle Biochemistry develops Royal Jelly-like peptide for skin regeneration


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Mibelle Biochemistry develops Royal Jelly-like peptide for skin regeneration

Related tags Amino acid

Mibelle Biochemistry has developed a peptide which mimics the function of Royalactin; a protein found in Royal Jelly responsible for the epigenetic programming of the queen bee; and it has been shown to have skin regeneration properties.

The Swiss firm showcased its latest innovation, RoyalEpigen P5 - a five amino acid peptide based on the epigenetic science of royal jelly, at the in-cosmetics 2016 event in Paris, with Managing Director Fred Zülli doing a presentation on it at the show too.

Inspired by epigenetic science, RoyalEpigen P5 has been designed to delay the ageing of skin. Both lifestyles and environmental factors have an impact on the epigenome of skin cells and thus influence their vitality.


This new ingredient is based on a biologically active peptide that mimics the function of royalactin, which is a protein that was recently discovered in royal jelly as being responsible for the epigenetic programming of queen bees.

Although identical on a genetic level, worker bees and the queen bee differ in life span, fertility and size. The reason for this is epigenetic changes in the queen bee that are evoked by the feeding of royal jelly.

As mentioned, recent scientific findings have shown that the component of royal jelly which drives queen bee development is the protein Royalactin, and this led Mibelle Biochemistry to develop a peptide that copies its active sequence.

For improved skin uptake, the peptide was also incorporated into a soft sphere carrier system based on shea butter.


According to the Buchs-based supplier, in a placebo-controlled clinical trial, RoyalEpigen P5 was shown to improve skin regeneration, firmness and smoothness. Furthermore, it evens out skin tone irregularities for a youthful complexion.

Epigenetics, the science of heritable biological adaptation, has become one of the outmost important fields of research today. Ageing, lifestyle, diet and exposure to environmental factors have an effect on the cellular function by influencing the epigenome of skin cells.

Related topics Formulation & Science Skin Care

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