According to the manufacturer, “it can be integrated in all repair treatments and regulates epidermal homeostasis by controlling calcium inflow into keratinocytes via the nicotinic acetylcholine receptor (nAChRs) pathway.”
The active ingredient enables the restoration of cellular organisation in the superficial skin layer which “thereby presents less squama but rather more hexagonal cells arranged in a honeycomb form.”
The effect of Nachyline on keratinocyte differentiation and adhesion via the nAChR pathway was studied with the use of a nicotinic acetylcholine receptor antagonist mecamylamine, according to a Silab spokesperson.
The ingredient was found to boost keratinocytes differentiation, reinforce the cohesion and stratification of epidermis and contribute to the organisation of the stratum corneum.
Tried and tested
In trials, the product was tested at 1 per cent and found to increase loricrin synthesis by 282 per cent. “In the presence of mecamylamine, a reversible nAChR inhibitor, the increase in loricrin synthesis was also significantly reduced by 58 per cent.”
It was also found to accelerate the construction of the epidermis and contribute to its cohesion and maturation by stimulating loricrin +22 per cent and E-cadherin +43 per cent.
Nachyline at 3 per cent limits impairments in the barrier function and thereby preserves the integrity of stratum corneum. After 14 days of twice daily applications, it significantly decreased water loss by 11 per cent.
In comparison to a placebo, a significant improvement of 25.7 per cent on the appearance of the skin was demonstrated when it was treated with 3 per cent Nachyline.