Lipoaminoacids provide comprehensive anti-ageing protection, study

By Katie Bird

- Last updated on GMT

Related tags Dna

Two new lipoaminoacid ingredients work in complementary ways to help fight against skin aging, according to a recent study.

Palmitoyl glycine and cocoyl alanine were studied using a number of in vitro ​and ex vivo ​techniques that illustrated their potential as new anti-aging actives, according to scientists at ingredients supplier SEPPIC which manufacturers the products.

The researchers used DNA arrays and quantitative polymerase chain reaction (qPCR) experiments to investigate the affect of the two actives on gene expression specifically genes known to be affected by age, as well as using human skin explants and fibroblast cultures.

Complementary actions

Early on in the study it became clear that the two actives did not have the same mode of action and therefore each was investigated singularly, explained the scientists.

Palmitoyl glycine (PG) prevented aging-induced gene expression involved in the inflammation pathways and the extra cellular matrix-degrading enzyme MMP-1 and tenascin, which is involved in the remodelling of the extra cellular matrix.

Cocoyl alanine (CA), conversely, had a restorative effect on the longevity marker sirtuin, as well as genes associated with cell-cell communication

This suggests the active can maintain cell and skin tissues in a healthy condition by delaying ageing associated changes.

The team also investigated the ability of PG to affect the microcirculation of the skin as this could have a radiance-giving effect often sought after in anti-ageing cosmetics.

According to the study, in vitro​ tests illustrated that PG promoted new vessel formation and these results were backed up by the use of skin explants where PG application to the skin led to an improvement in luminosity.

New prospects for fight against ageing

The researchers concluded that together the actives had a complementary effect and therefore led to both a regulation and restoration effect on some of the main ageing-associated disorders.

Acting on tissue architecture, cell-cell interaction, cell longevity and the extra cellular matrix, the actives are ‘new prospects’ in the fight against skin ageing, they concluded.

Source: International Journal of Cosmetic Science
​doi: 10.1111/j.1468-2494.2009.00525.x
Two new lipoaminoacids with complementary modes of action: new prospects to fight out against skin ageing
​S Dumont, L Cattuzzato, G Trouvé, N Chevrot and C Stoltz

Related news

Related products

show more

Calendula Cellular Elixir: Alchemy in a cell

Calendula Cellular Elixir: Alchemy in a cell

Content provided by Naolys | 24-Apr-2024 | Product Brochure

Get ready to experience a cellular evolution in skincare with InnerLift Calendula's advanced Plant Cell biotechnology.

See our latest innovations in personal care

See our latest innovations in personal care

Content provided by Covation Bio™ PDO | 02-Apr-2024 | White Paper

At CovationBio PDO, we’re helping the world achieve its sustainability goals by enabling better performing, better-for-the planet products across a range...

Collagen Reimagined, Discover Biodesigned Type XXI

Collagen Reimagined, Discover Biodesigned Type XXI

Content provided by Geltor | 20-Mar-2024 | Product Brochure

Collagen is the body’s most abundant protein and a mainstream ingredient for beauty. Type XXI collagen transcends a common protein into a powerful bioactive

Empowering natural barrier function for future-proof skin

Empowering natural barrier function for future-proof skin

Content provided by Lucas Meyer Cosmetics | 14-Mar-2024 | White Paper

Corneopeptyl™ is a new patented peptide biomimetic to the LCE6A protein, obtained by green chemistry-based synthesis. By mimicking the LCE6A protein activity,...

Related suppliers

Follow us


View more



Beauty 4.0 Podcast