Hyaluronic acid has become the must have anti-wrinkle ingredient, but now France-based Silab has launched what it claims is a natural-based alternative.
Prohyal+ is derived from Mexican blue agave leaves and is being marketed as a next generation hyaluronic acid ingredient that targets unprecedented anti-wrinkle results.
The secret to its claimed efficacy? According to the Silab R&D team, the ingredient targets the endogenous synthesis of hyaluronic acid, which gives it the ability to penetrate both the skin tissue and skin cells.
In vitro and in vivo studies
The Silab R&D team say they have conducted extensive in vitro and in vivo studies to measure the efficacy of the ingredient on fine lines and wrinkles, with documented results.
The studies have shown results demonstrating increased expression of hyaluronan synthase(HAS2) synthesis enzyme, which in turn reactivates the natural mechanism of hyaluronic acid production, a natural process in skin cells that depletes with age.
Likewise, the studies also show that the ingredient treats the signs of age by rehydrating it and giving microrelief to the face that can visibly relieve fine lines and wrinkles.
Two per cent dose showed maximum efficacy
The study considered a control ingredient, together with Prohyal+ doses of 0.5, 1 and 2 percent to determine the effect on both levels of HAS2 hyaluronan synthase and the synthesis of hyaluronic acid.
According to the study report, the results of these tests showed that a 2 per cent dose of the ingredient increases the expression of HAS2 by 651 per cent, while promoting the synthesis of hyaluronic acid by 237 per cent.
The study results on the skin of volunteers showed that after 28 days of twice daily applications, the ingredient visibly smoothed skin around the crow’s feet, showing measureable parameter Sq and Parameter Sa results that were reduced by 6.3 per cent and 7.1 per cent respectively.
Ultimately the research team claims that the new ingredient has similar efficacy to hyaluronic acid, reducing the volume of wrinkes by an average of 14.2 per cent in 70 per cent of the volunteers it was tested on.