In people genetically susceptible to hair loss, dihydrotestosterone (DHT) binding to receptors in hair follicles induces progressive baldness. DHT is made from testosterone by the enzyme 5-alpha reductase. It seems that DHT causes the release of IL 6, an inflammatory molecule repressing elongation of the hair, following inflammation surrounding the hair follicle. Pomanox® inhibits IL6 gene expression and plasma levels and demonstrated significant increased hair density and thickness after 60 days of treatment. On the other hand, Prosterol® exhibited a significant inhibition of 5-alpha reductase activity in human dermal fibroblasts.